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Stomach Cancer

Was diagnosed with gastric signet ring cell carcinoma 2 years ago. Is he/she still doing well now?

时间：2026-04-22　人气：

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Overview of the condition

In August 2021, Mr. Wang underwent a CT scan and discovered a space-occupying lesion in his stomach. To clarify its nature, he underwent gastroscopy and biopsy: it was diagnosed as poorly differentiated adenocarcinoma of the gastric antrum, with visible signet-ring cells; HP (-).

After being diagnosed with gastric cancer, Mr. Wang immediately underwent a modified II gastrectomy with lymph node dissection. Postoperative pathology revealed: (distal stomach) poorly differentiated adenocarcinoma, with some areas showing signet-ring cell changes, and some regions accompanied by extracellular mucin secretion; invasion of the serosal layer; visible nerve and vascular invasion; tumor involvement at the upper resection margin, with the lower resection margin being (-) negative. A total of 50 lymph nodes were examined, with 27 showing metastatic cancer (27/50).

Due to his advanced age and poor tolerance to surgery, Mr. Wang was immediately transferred to the ICU for observation after the operation, and no chemotherapy was administered postoperatively.

Department

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Knowledge

Gastric signet-ring cell carcinoma

Signet-ring cell carcinoma is a type of poorly differentiated adenocarcinoma with high malignancy, prone to diffuse infiltrative growth in the gastric wall, strong invasiveness, and high metastatic rate, often being detected at an advanced stage. Signet-ring cell carcinoma is a special type of gastric cancer containing a large amount of mucus.

The current main treatment for signet-ring cell carcinoma still relies on early detection and surgical resection. Due to its high malignancy, surgery is not recommended once metastasis occurs. However, signet-ring cell carcinoma is not sensitive to chemotherapy, so traditional treatments have limited effects on patients in advanced stages.

In recent years, with the development of molecular biology and tumor biology, various new immunotherapies for tumors have emerged, becoming another effective treatment method for tumors after surgery, radiotherapy, chemotherapy, and targeted therapy.

After reviewing Mr. Wang's medical records, Professor Zhang Minghui made the following analysis and judgment:

1. The patient has undergone complete surgical treatment for signet-ring cell carcinoma.

2. Signet-ring cell carcinoma is highly malignant, and patients with this disease are at risk for vascular thrombi and lymph node metastasis, and have not completed postoperative chemoradiotherapy.

3. NKT cell therapy utilizes powerful immune cells to eliminate tumor cells that may remain in the body, with essentially no side effects, making it very friendly for elderly patients like Mr. Wang.

In January 2022, Mr. Wang began to receive NKT cell immunotherapy, and by March 2023, he had completed 13 courses of treatment. Mr. Wang's tumor had multiple risks of recurrence and metastasis, so immunocyte therapy intervention was performed. During the treatment process of more than half a year, no clear signs of tumor recurrence or metastasis were observed in two follow-up examinations, and his overall condition remained stable.

In terms of imagery

Tumor markers

Month

CEA: within the normal range from August 2021 to May 2022;

CA19-9: increased from August 2021 to September 2021, and returned to normal upon reexamination in May 2022;

CA724: higher than normal during reexaminations from December 2021 to March 2023, with an increasing trend from March 2022 to July 2022, decreased in October 2022, significantly increased upon reexamination in January 2023, and slightly decreased upon reexamination in March 2023;

CA242: beyond the normal range during reexaminations from October 2022 to March 2023, with an increasing trend; ferritin higher than normal from March 2022 to March 2023, regular reexamination recommended.

Conclusion and Comments

Mr. Wang reported that the patient's physical condition had improved to some extent, and he felt more energetic than before. The quality of life score was 55.5 (previously 52).

Mr. Wang had risk factors such as vascular thrombi and lymph node metastasis when the tumor was discovered, and subsequently received NKT cell therapy after surgery. Over more than a year, multiple follow-ups showed stable disease without progression.

Gastric cancer is a highly common malignant tumor, ranking fifth in incidence rate and fourth in mortality rate globally. According to the World Health Organization's classification, gastric adenocarcinoma can be broadly divided into four histological types: mucinous adenocarcinoma, renal tubular adenocarcinoma, signet-ring cell carcinoma (SRC), and adenocarcinoma. SRC is considered the histological type with the worst prognosis due to its low survival rate and high recurrence rate. It has been proven that GSRC is highly aggressive, and once detected, most of it is in the advanced stage of lymph node metastasis.

Due to the high malignancy and multiple risk factors of Mr. Wang's tumor, he would typically have lost the opportunity for long-term survival. However, with the combination of various treatments, Mr. Wang's condition stabilized. In this process, NKT cell immunotherapy played an indispensable role in reducing the risk of recurrence and metastasis. It not only eliminated residual tumor cells but also strengthened the immune system, thereby providing long-term stability for the patient.

Popular science knowledge is provided for reference only, and individual patients should seek clinical medical advice.

Reference:< H410>

【1】Tian HK, Zhang Z, Ning ZK, Liu J, Liu ZT, Huang HY, Zong Z, Li H. Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma. World J Clin Cases 2022; 10(29): 10451-10466 [PMID: 36312481 DOI: 10.12998/wjcc.v10.i29.10451]

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Was diagnosed with gastric signet ring cell carcinoma 2 years ago. Is he/she still doing well now?

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